ABSTRACT
<p><b>INTRODUCTION</b>Liver biopsy is considered the definitive investigation in the diagnosis and management of liver disease. This study describes the experience of performing transjugular liver biopsy (TJLB) over the last 9 years in a local single centre.</p><p><b>MATERIALS AND METHODS</b>A retrospective review of consecutive TJLB procedures performed at our institution was conducted. A total of 152 patients (74 males and 78 females), with a mean age of 47.4 years (range, 13 to 83 years) underwent a total of 154 TJLB procedures at our institution between March 2003 and November 2011. The principal indication for TJLB was severe coagulopathy in over 80% of patients. The technical success, number of passes, histological adequacy and complication rates were analysed.</p><p><b>RESULTS</b>The procedural success rate was 98.7% (152 out of 154 procedures). Adequate material for diagnosis was obtained in 149 out of 152 (98.0%) technically successful procedures. There was procedure related morbidity in 8 patients (5.2%) of which all but one were self-limiting requiring no further intervention. We also performed hepatic venous pressure gradient (HVPG) measurements in 19% of patients at the time of TJLB.</p><p><b>CONCLUSION</b>TJLB performed at our institution is a safe and reliable technique in patients in whom traditional percutaneous liver biopsy may be hazardous. TJLB has a high technical success rate as well as a high diagnostic yield with a low complication rate. TJLB also has the added benefit of performing HVPG, which is of increasing importance in management and prognostication of chronic liver disease.</p>
Subject(s)
Adolescent , Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Young Adult , Biopsy , Methods , Jugular Veins , Liver , Pathology , Liver Diseases , Pathology , Retrospective StudiesABSTRACT
Extramedullary plasmacytoma of the pancreas is a rare entity. Although this condition is uncommon, it should be considered in the differential diagnosis of solid mass in the pancreas, especially in patients with underlying multiple myeloma. We report a case of pancreatic plasmacytoma in a 56-year-old woman with newly diagnosed multiple myeloma. We highlight this rare manifestation of multiple myeloma among other better recognised presentations.
Subject(s)
Female , Humans , Middle Aged , Diagnosis, Differential , Immunohistochemistry , Keratins , Metabolism , Multiple Myeloma , Diagnosis , Pathology , Pancreas , Pathology , Pancreatic Neoplasms , Diagnosis , Pathology , Plasmacytoma , Diagnosis , Pathology , Syndecan-1 , MetabolismABSTRACT
Pattern of liver disease in patients was studied who visited Sheikh Zayed Hospital and were referred to the Department of Histopathology. A total of 427 cases, excluding FNA, were received in the 6 years between 1988 and 1993. The commonest disorders found included cirrhosis, metastatic Carcinoma, Chronic Active hepatitis, hepatocellular Carcinoma and steatosis
Subject(s)
Humans , Male , Female , Hepatitis/complications , Biopsy, Needle , /methods , Liver Cirrhosis/etiology , Liver Cirrhosis/diagnosis , LaparoscopyABSTRACT
A case of Goblet cell carcinoid is presented where a female patient reported to the hospital with the history of constipation alternating with diarrhea and passage of black colored stools on at least three occasions during the past four months. In the past 15 days, she had experienced episodic abdominal distension with vomiting. The patient had also lost weight during this period. Initially a clinical disgnosis of illeo-cecal tuberculosis was made and right hemicolectomy was performed. On histopathological examination of the specimens, goblet cell carcinoid was diagnosed